Katrin Hinrichs

Additional Appointment Titles

• Chair, Department of Clinical Studies-New Bolton Center, University of Pennsylvania School of Veterinary Medicine
• Harry Werner Endowed Professor of Equine Medicine, University of Pennsylvania School of Veterinary Medicine
• Professor of Reproduction, University of Pennsylvania School of Veterinary Medicine

Education

• DVM (Veterinary Medicine-Equine Track)
  University of California-Davis, 1978.
• PhD (Biomedical Graduate Group)
  University of Pennsylvania, 1988.

Post-Graduate Training

• Resident, Large Animal Reproduction, University of Pennsylvania School of Veterinary Medicine, 1982-1984.

Description of Clinical Expertise

Equine reproduction, Reproductive medicine

Description of Research Expertise

Dr. Hinrichs’ research efforts include diagnostic and clinical health areas, such as:

• Equine reproductive management
• Reproductive medicine
• Embryo transfer
• Reproductive surgery

Past research includes

• Use of time-lapse imaging to evaluate morphokinetics of in vitro equine blastocyst development
• Effect of intra-ovarian injection of mesenchymal stem cells in aged mares
• Equine fetal genotyping via aspiration of yolk-sac fluid at 22-28 days of gestation
• Intrafollicular oocyte transfer in the horse
• Conventional vs. Piezo ICSI in the horse: delayed sperm component remodeling and oocyte activation
• Vitrification of germinal-vesicle stage equine oocytes
• Culture of somatic cells isolated from frozen-thawed equine semen using fluorescence-assisted cell sorting
• Accuracy of preimplantation genetic diagnosis in equine in vivo-recovered and in vitro-produced blastocysts
• Cell lineage allocation in equine blastocysts cultured in varying glucose concentrations
• Timing factors affecting blastocyst development in equine somatic cell nuclear transfer
• Regulation of axonemal motility in demembranated equine sperm

Selected Publications

Angel, D., Canesin, H. S., Brom-de-Luna, J. G., Morado, S., Dalvit, G., Gomez, D., Posada, N., Pascottini, O. B., Urrego, R., Hinrichs, K., Velez, I. C.: Embryo development after vitrification of immature and in vitro-matured equine oocytes. Cryobiology 2020.

Ripley, A. M., Penedo, M. C. T., Grahn, R. A., Martinez de Andino, E. V., Walbornn, S. R., Serafini, R., Love, C. C., Hinrichs, K.: Equine fetal genotyping via aspiration of yolk-sac fluid at 22–28 days of gestation. Theriogenology 142: 34-40, 2020.

Brom-De-Luna, J. G., Salgado, R. M., Canesin, H. S., Diaw, M., Hinrichs, K.: Equine blastocyst production under different incubation temperatures and different CO2 concentrations during early cleavage. Reproduction, Fertility and Development 31(12): 1823-1829, 2019.

Marzano, G., Mastrorocco, A., Zianni, R., Mangiacotti, M., Chiaravalle, A. E., Lacalandra, G. M., Minervini, F., Cardinali, A., Macciocca, M., Vicenti, R., Fabbri, R., Hinrichs, K., Dell’Aquila, M. E., Martino, N. A.: Altered morphokinetics in equine embryos from oocytes exposed to DEHP during IVM. Molecular Reproduction and Development 86(10): 1388-1404, 2019.

Martino, N. A., Marzano, G., Mastrorocco, A., Lacalandra, G. M., Vincenti, L., Hinrichs, K., Dell’Aquila, M. E.: Use of time-lapse imaging to evaluate morphokinetics of in vitro equine blastocyst development after oocyte holding for two days at 15°C versus room temperature before intracytoplasmic sperm injection. Reproduction, Fertility and Development 31(12): 1862-1873, 2019.

Martinez de Andino, E., Brom-de-Luna, J., Canesin, H., Rader, K., Resende, H., Ripley, A., Love, C., Hinrichs, K.: Intrafollicular oocyte transfer in the horse: effect of autologous vs. allogeneic transfer and time of administration of ovulatory stimulus before transfer. Journal of Assisted Reproduction and Genetics 36(6): 1237-1250, 2019.

Lewis, N., Schnauffer, K., Hinrichs, K., Morganti, M., Troup, S., Argo, C.: Morphokinetics of early equine embryo development in vitro using time-lapse imaging, and use in selecting blastocysts for transfer. Reproduction, Fertility and Development 31(12): 1851-1861, 2019.

Kelley, D. E., Hodo, C. L., Aceino, A., Lawhon, S. D., Hinrichs, K., Brinsko, S. P.: Abortion due to Bacillus pumilus in a mare. Equine Veterinary Education 2019.

Grady, S. T., Watts, A. E., Thompson, J. A., Penedo, M. C. T., Konganti, K., Hinrichs, K.: Effect of intra-ovarian injection of mesenchymal stem cells in aged mares. Journal of Assisted Reproduction and Genetics 36(3): 543-556, 2019.

Grady, S. T., Britton, L., Hinrichs, K., Nixon, A. J., Watts, A. E.: Persistence of fluorescent nanoparticle-labelled bone marrow mesenchymal stem cells in vitro and after intra-articular injection. Journal of Tissue Engineering and Regenerative Medicine 13(2): 191-202, 2019.